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Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
BACKGROUND: Targeting epitopes derived from neo-antigens (or “neo-epitopes”) represents a promising immunotherapy approach with limited off-target effects. However, most peptides predicted using MHC binding prediction algorithms do not induce a CD8 + T cell response, and there is a crucial need to r...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532181/ https://www.ncbi.nlm.nih.gov/pubmed/31118084 http://dx.doi.org/10.1186/s40425-019-0595-z |