Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes

BACKGROUND: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutations affecting UBE3A gene expression. Previous studies in mice revealed distinct critical periods during neurodevelopment in which reactivation of Ube3a gene expression can prevent the onset of behavioral defic...

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Detalles Bibliográficos
Autores principales: Sonzogni, Monica, Hakonen, Johanna, Bernabé Kleijn, Mireia, Silva-Santos, Sara, Judson, Matthew C., Philpot, Benjamin D., van Woerden, Geeske M., Elgersma, Ype
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532248/
https://www.ncbi.nlm.nih.gov/pubmed/31143434
http://dx.doi.org/10.1186/s13229-019-0277-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532248/
https://www.ncbi.nlm.nih.gov/pubmed/31143434
http://dx.doi.org/10.1186/s13229-019-0277-1

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