Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapy response in vitro and in vivo mouse model of human non-small-cell lung cancer

Pyruvate kinase M2 (PKM2) is an alternatively spliced variant, which mediates the conversion of glucose to lactate in cancer cells under normoxic conditions, known as the Warburg effect. Previously, we demonstrated that PKM2 is one of 97 genes that are overexpressed in non-small-cell lung cancer (NS...

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Detalles Bibliográficos
Autores principales: Suzuki, Akiko, Puri, Sachin, Leland, Pamela, Puri, Ankit, Moudgil, Tarsem, Fox, Bernard A., Puri, Raj K., Joshi, Bharat H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532891/
https://www.ncbi.nlm.nih.gov/pubmed/31120964
http://dx.doi.org/10.1371/journal.pone.0217131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532891/
https://www.ncbi.nlm.nih.gov/pubmed/31120964
http://dx.doi.org/10.1371/journal.pone.0217131

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