Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity

Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation...

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Autores principales: Sahlol, Nahla Yassin, Mostafa, Marwa Salah, Madkour, Lamiaa Abd El-Fattah, Salama, Dina Metwally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532901/
https://www.ncbi.nlm.nih.gov/pubmed/31120955
http://dx.doi.org/10.1371/journal.pone.0217352
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author Sahlol, Nahla Yassin
Mostafa, Marwa Salah
Madkour, Lamiaa Abd El-Fattah
Salama, Dina Metwally
author_facet Sahlol, Nahla Yassin
Mostafa, Marwa Salah
Madkour, Lamiaa Abd El-Fattah
Salama, Dina Metwally
author_sort Sahlol, Nahla Yassin
collection PubMed
description Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (r(s =) -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. Enhancing the expression and/or function of TNFAIP3 in the affected cell type may be a promising therapeutic strategy.
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spelling pubmed-65329012019-06-05 Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity Sahlol, Nahla Yassin Mostafa, Marwa Salah Madkour, Lamiaa Abd El-Fattah Salama, Dina Metwally PLoS One Research Article Psoriasis vulgaris is a systemic disorder with an underlying immune dysregulation that predisposes to inflammatory skin lesions. Meanwhile, tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been described as a protective molecule against the deleterious effects of uncontrolled inflammation. In this study, we compared the expression levels of TNFAIP3 in blood and psoriatic skin biopsies from psoriatic patients versus those in normal individuals. Additionally, the levels of TNFAIP3 protein in psoriatic skin biopsies were compared to those in normal individuals. Thirty psoriatic patients and 30 healthy participants (control group) were enrolled. The expression levels of TNFAIP3 in blood and skin were measured by quantitative reverse transcription PCR, while the skin levels of TNFAIP3 protein were measured by western blot. Psoriatic patients showed significantly lower expression levels of TNFAIP3 in psoriatic skin and blood (P< 0.001) as well as of TNFAIP3 protein in psoriatic skin (P< 0.001) compared to controls. A significant lower expression of TNFAIP3 and TNFAIP3 protein in psoriatic skin was detected in moderate/severe cases compared to mild cases (P = 0.004 and 0.003 respectively). Moreover, a significant negative correlation was found between TNFAIP3 mRNA in psoriatic tissue and psoriasis area severity index values (r(s =) -0.382, P-value = 0.037). In conclusion, TNFAIP3 may serve as a predictive and prognostic biomarker in psoriatic patients. Enhancing the expression and/or function of TNFAIP3 in the affected cell type may be a promising therapeutic strategy. Public Library of Science 2019-05-23 /pmc/articles/PMC6532901/ /pubmed/31120955 http://dx.doi.org/10.1371/journal.pone.0217352 Text en © 2019 Sahlol et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sahlol, Nahla Yassin
Mostafa, Marwa Salah
Madkour, Lamiaa Abd El-Fattah
Salama, Dina Metwally
Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title_full Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title_fullStr Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title_full_unstemmed Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title_short Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity
title_sort low tnfaip3 expression in psoriatic skin promotes disease susceptibility and severity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532901/
https://www.ncbi.nlm.nih.gov/pubmed/31120955
http://dx.doi.org/10.1371/journal.pone.0217352
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