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Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis

Transition bias, an overabundance of transitions relative to transversions, has been widely reported among studies of the rates and spectra of spontaneous mutations. However, demonstrating the role of transition bias in adaptive evolution remains challenging. In particular, it is unclear whether suc...

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Detalles Bibliográficos
Autores principales: Payne, Joshua L., Menardo, Fabrizio, Trauner, Andrej, Borrell, Sonia, Gygli, Sebastian M., Loiseau, Chloe, Gagneux, Sebastien, Hall, Alex R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532934/
https://www.ncbi.nlm.nih.gov/pubmed/31083647
http://dx.doi.org/10.1371/journal.pbio.3000265