Cbl interacts with multiple E2s in vitro and in cells

Many receptor tyrosine kinases (RTKs, such as EGFR, MET) are negatively regulated by ubiquitination and degradation mediated by Cbl proteins, a family of RING finger (RF) ubiquitin ligases (E3s). Loss of Cbl protein function is associated with malignant transformation driven by increased RTK activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Liyasova, Mariya S., Ma, Ke, Voeller, Donna, Ryan, Philip E., Chen, Jinqiu, Klevit, Rachel E., Lipkowitz, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533038/
https://www.ncbi.nlm.nih.gov/pubmed/31120930
http://dx.doi.org/10.1371/journal.pone.0216967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533038/
https://www.ncbi.nlm.nih.gov/pubmed/31120930
http://dx.doi.org/10.1371/journal.pone.0216967

Ejemplares similares