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Cbl interacts with multiple E2s in vitro and in cells
Many receptor tyrosine kinases (RTKs, such as EGFR, MET) are negatively regulated by ubiquitination and degradation mediated by Cbl proteins, a family of RING finger (RF) ubiquitin ligases (E3s). Loss of Cbl protein function is associated with malignant transformation driven by increased RTK activit...
Autores principales: | Liyasova, Mariya S., Ma, Ke, Voeller, Donna, Ryan, Philip E., Chen, Jinqiu, Klevit, Rachel E., Lipkowitz, Stanley |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533038/ https://www.ncbi.nlm.nih.gov/pubmed/31120930 http://dx.doi.org/10.1371/journal.pone.0216967 |
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