Pharmacokinetic comparison of a diverse panel of non-targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non-human primates

In this study we compared the pharmacokinetic profile of four unrelated antibodies, which do not bind to mammalian antigens, in IgG1 and IgG2 frameworks in both rats and non-human primates (NHP). This allowed for extensive cross comparison of the impact of antibody isotype, complementarity determini...

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Detalles Bibliográficos
Autores principales: Walker, Kenneth W., Salimi-Moosavi, Hossein, Arnold, Gregory E., Chen, Qing, Soto, Marcus, Jacobsen, Frederick W., Hui, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533040/
https://www.ncbi.nlm.nih.gov/pubmed/31120944
http://dx.doi.org/10.1371/journal.pone.0217061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533040/
https://www.ncbi.nlm.nih.gov/pubmed/31120944
http://dx.doi.org/10.1371/journal.pone.0217061

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