HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Iron and heme play central roles in the production of red blood cells, but the underlying mechanisms remain incompletely understood. Heme-regulated eIF2α kinase (HRI) controls translation by phosphorylating eIF2α. Here, we investigate the global impact of iron, heme, and HRI on protein translation i...

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Detalles Bibliográficos
Autores principales: Zhang, Shuping, Macias-Garcia, Alejandra, Ulirsch, Jacob C, Velazquez, Jason, Butty, Vincent L, Levine, Stuart S, Sankaran, Vijay G, Chen, Jane-Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533081/
https://www.ncbi.nlm.nih.gov/pubmed/31033440
http://dx.doi.org/10.7554/eLife.46976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533081/
https://www.ncbi.nlm.nih.gov/pubmed/31033440
http://dx.doi.org/10.7554/eLife.46976

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