PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier pr...

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Detalles Bibliográficos
Autores principales: Shi, Kaixuan, Yin, Xia, Cai, Mei-Chun, Yan, Ying, Jia, Chenqiang, Ma, Pengfei, Zhang, Shengzhe, Zhang, Zhenfeng, Gu, Zhenyu, Zhang, Meiying, Di, Wen, Zhuang, Guanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533083/
https://www.ncbi.nlm.nih.gov/pubmed/31050342
http://dx.doi.org/10.7554/eLife.44306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533083/
https://www.ncbi.nlm.nih.gov/pubmed/31050342
http://dx.doi.org/10.7554/eLife.44306

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