Cargando…

PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Kaixuan, Yin, Xia, Cai, Mei-Chun, Yan, Ying, Jia, Chenqiang, Ma, Pengfei, Zhang, Shengzhe, Zhang, Zhenfeng, Gu, Zhenyu, Zhang, Meiying, Di, Wen, Zhuang, Guanglei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533083/ https://www.ncbi.nlm.nih.gov/pubmed/31050342 http://dx.doi.org/10.7554/eLife.44306

Ejemplares similares

Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer
por: Zhang, Shengzhe, et al.
Publicado: (2015)

BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1
por: Zhang, Zhenfeng, et al.
Publicado: (2016)

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
por: Zhang, Shengzhe, et al.
Publicado: (2018)

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer
por: Jing, Ying, et al.
Publicado: (2015)

HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
por: Sun, Jun, et al.
Publicado: (2021)

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis
por: Jia, Chenqiang, et al.
Publicado: (2021)

Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics
por: Zhang, Meiying, et al.
Publicado: (2015)

HDAC6 and Ovarian Cancer
por: Haakenson, Joshua, et al.
Publicado: (2013)

PAX8 lineage-driven T cell engaging antibody for the treatment of high-grade serous ovarian cancer
por: Lee, Emily, et al.
Publicado: (2021)

Pax7 Lineage Contributions to the Mammalian Neural Crest
por: Murdoch, Barbara, et al.
Publicado: (2012)

UnPAXing the Divergent Roles of PAX2 and PAX8 in High-Grade Serous Ovarian Cancer
por: Hardy, Laura R., et al.
Publicado: (2018)

TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer
por: Zhang, Meiying, et al.
Publicado: (2017)

Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma
por: Que, Yi, et al.
Publicado: (2021)

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells
por: La Greca, Alejandro, et al.
Publicado: (2022)

PAX2 Expression in Ovarian Cancer
por: Song, Huijuan, et al.
Publicado: (2013)

Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos
por: Nord, Hanna, et al.
Publicado: (2016)

Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma
por: Chen, Minjiang, et al.
Publicado: (2023)

The paradigm of drug resistance in cancer: an epigenetic perspective
por: Adhikari, Swagata, et al.
Publicado: (2022)

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis
por: Kendall, Genevieve C, et al.
Publicado: (2018)

PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis
por: Yun, Bo Seong, et al.
Publicado: (2022)

Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
por: Sergi, Consolato M.
Publicado: (2021)

PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling
por: Gao, Hongmin, et al.
Publicado: (2019)

Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211
por: Zhang, Hairong, et al.
Publicado: (2021)

HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function
por: Liu, Queping, et al.
Publicado: (2017)

High expression of sperm-associated antigen 5 correlates with poor survival in ovarian cancer
por: Zhang, Mei, et al.
Publicado: (2020)

Significant under expression of the DosR regulon in M. tuberculosis complex lineage 6 in sputum
por: Ofori-Anyinam, Boatema, et al.
Publicado: (2017)

PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study
por: Lai, Hung-Cheng, et al.
Publicado: (2014)

The PAX8 cistrome in epithelial ovarian cancer
por: Adler, Emily K., et al.
Publicado: (2017)

Identification and validation of a prognostic index based on a metabolic-genomic landscape analysis of ovarian cancer
por: Zhang, Qun-feng, et al.
Publicado: (2020)

Long non-coding RNA ARAP1-AS1 accelerates cell proliferation and migration in breast cancer through miR-2110/HDAC2/PLIN1 axis
por: Lu, Chong, et al.
Publicado: (2020)

FOXA1 can be modulated by HDAC3 in the progression of epithelial ovarian carcinoma
por: Lou, Tong, et al.
Publicado: (2022)

Epigenetic regulation of interleukin-8 expression by class I HDAC and CBP in ovarian cancer cells
por: Gatla, Himavanth R., et al.
Publicado: (2017)

lncRNA ABHD11‐AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2
por: Zeng, Xiang‐Yang, et al.
Publicado: (2019)

Genomic Arrangement of Regulons in Bacterial Genomes
por: Zhang, Han, et al.
Publicado: (2012)

Meta-analysis based gene expression profiling reveals functional genes in ovarian cancer
por: Zhao, Lin, et al.
Publicado: (2020)

Development and validation of a nomogram to predict synchronous lung metastases in patients with ovarian cancer: a large cohort study
por: Yuan, Yufei, et al.
Publicado: (2020)

CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2
por: Boucheron, Nicole, et al.
Publicado: (2014)

Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer
por: Soto, Javier Andrés, et al.
Publicado: (2021)

Integrated molecular profiling of patient‐derived ovarian cancer models identifies clinically relevant signatures and tumor vulnerabilities
por: Lupia, Michela, et al.
Publicado: (2022)

Efficacy and safety of PARP inhibitors as the maintenance therapy in ovarian cancer: a meta-analysis of nine randomized controlled trials
por: Shao, Fengping, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2a37lvehs5s45863psvncs54v0