Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity

Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (T(H)2)-mediated allergic diseases such as asthma and atopic dermatitis. Here we isolated anti-human IL-4Rα antagonistic Abs from...

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Detalles Bibliográficos
Autores principales: Kim, Jung-Eun, Jung, Keunok, Kim, Jeong-Ah, Kim, Seung-Hyun, Park, Hae-Sim, Kim, Yong-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533264/
https://www.ncbi.nlm.nih.gov/pubmed/31123339
http://dx.doi.org/10.1038/s41598-019-44253-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533264/
https://www.ncbi.nlm.nih.gov/pubmed/31123339
http://dx.doi.org/10.1038/s41598-019-44253-9

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