Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos

Precise genome editing is limited by the inefficiency of homology-directed repair (HDR) compared to the non-homologous end-joining (NHEJ) of double strand breaks (DSBs). The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 system generates precise, locus-specific DSBs that can...

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Detalles Bibliográficos
Autores principales: Aksoy, Yagiz A., Nguyen, David T., Chow, Sharron, Chung, Roger S., Guillemin, Gilles J., Cole, Nicholas J., Hesselson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533270/
https://www.ncbi.nlm.nih.gov/pubmed/31149642
http://dx.doi.org/10.1038/s42003-019-0444-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533270/
https://www.ncbi.nlm.nih.gov/pubmed/31149642
http://dx.doi.org/10.1038/s42003-019-0444-0

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