ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes

Impaired insulin secretion from pancreatic islets is a hallmark of type 2 diabetes (T2D). Altered chromatin structure may contribute to the disease. We therefore studied the impact of T2D on open chromatin in human pancreatic islets. We used assay for transposase-accessible chromatin using sequencin...

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Detalles Bibliográficos
Autores principales: Bysani, Madhusudhan, Agren, Rasmus, Davegårdh, Cajsa, Volkov, Petr, Rönn, Tina, Unneberg, Per, Bacos, Karl, Ling, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533306/
https://www.ncbi.nlm.nih.gov/pubmed/31123324
http://dx.doi.org/10.1038/s41598-019-44076-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533306/
https://www.ncbi.nlm.nih.gov/pubmed/31123324
http://dx.doi.org/10.1038/s41598-019-44076-8

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