Regulation of drug metabolizing enzymes in the leukaemic bone marrow microenvironment

The bone marrow (BM) microenvironment contributes to drug resistance in acute myeloid leukaemia (AML) and multiple myeloma (MM). We have shown that the critical drug metabolizing enzymes cytochrome P450 (CYP) 3A4 and cytidine deaminase (CDA) are highly expressed by BM stroma, and play an important r...

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Detalles Bibliográficos
Autores principales: Su, Meng, Chang, Yu‐Ting, Hernandez, Daniela, Jones, Richard J., Ghiaur, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533513/
https://www.ncbi.nlm.nih.gov/pubmed/30920135
http://dx.doi.org/10.1111/jcmm.14298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533513/
https://www.ncbi.nlm.nih.gov/pubmed/30920135
http://dx.doi.org/10.1111/jcmm.14298

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