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Regulation of drug metabolizing enzymes in the leukaemic bone marrow microenvironment
The bone marrow (BM) microenvironment contributes to drug resistance in acute myeloid leukaemia (AML) and multiple myeloma (MM). We have shown that the critical drug metabolizing enzymes cytochrome P450 (CYP) 3A4 and cytidine deaminase (CDA) are highly expressed by BM stroma, and play an important r...
Autores principales: | Su, Meng, Chang, Yu‐Ting, Hernandez, Daniela, Jones, Richard J., Ghiaur, Gabriel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533513/ https://www.ncbi.nlm.nih.gov/pubmed/30920135 http://dx.doi.org/10.1111/jcmm.14298 |
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