The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation

PURPOSE: Mutations in connexin50 (Cx50) and connexin46 (Cx46) cause cataracts. Because the expression of Cx46fs380 leads to decreased gap junctional coupling and formation of calcium precipitates, we studied Cx50D47A lenses to test whether Cx50 mutants also cause cataracts due to calcium precipitati...

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Detalles Bibliográficos
Autores principales: Berthoud, Viviana M., Gao, Junyuan, Minogue, Peter J., Jara, Oscar, Mathias, Richard T., Beyer, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Lens
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534014/
https://www.ncbi.nlm.nih.gov/pubmed/31117126
http://dx.doi.org/10.1167/iovs.18-26459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534014/
https://www.ncbi.nlm.nih.gov/pubmed/31117126
http://dx.doi.org/10.1167/iovs.18-26459

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