Cargando…

The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation

PURPOSE: Mutations in connexin50 (Cx50) and connexin46 (Cx46) cause cataracts. Because the expression of Cx46fs380 leads to decreased gap junctional coupling and formation of calcium precipitates, we studied Cx50D47A lenses to test whether Cx50 mutants also cause cataracts due to calcium precipitati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berthoud, Viviana M., Gao, Junyuan, Minogue, Peter J., Jara, Oscar, Mathias, Richard T., Beyer, Eric C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Lens
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534014/ https://www.ncbi.nlm.nih.gov/pubmed/31117126 http://dx.doi.org/10.1167/iovs.18-26459

Ejemplares similares

Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization
por: Berthoud, Viviana M., et al.
Publicado: (2020)

Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice
por: Minogue, Peter J., et al.
Publicado: (2017)

Do Connexin Mutants Cause Cataracts by Perturbing Glutathione Levels and Redox Metabolism in the Lens?
por: Jara, Oscar, et al.
Publicado: (2020)

Connexin Mutants Cause Cataracts Through Deposition of Apatite
por: Minogue, Peter J., et al.
Publicado: (2022)

Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice
por: Jara, Oscar, et al.
Publicado: (2022)

Connexin Mutants and Cataracts
por: Beyer, Eric C., et al.
Publicado: (2013)

CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice
por: Minogue, Peter J., et al.
Publicado: (2019)

Connexin 50 Regulates Surface Ball-and-Socket Structures and Fiber Cell Organization
por: Wang, Eddie, et al.
Publicado: (2016)

Connexin 50 and AQP0 are Essential in Maintaining Organization and Integrity of Lens Fibers
por: Gu, Sumin, et al.
Publicado: (2019)

Connexin 50-R205G Mutation Perturbs Lens Epithelial Cell Proliferation and Differentiation
por: Tjahjono, Nikki, et al.
Publicado: (2020)

Characterization of a Novel Gja8 (Cx50) Mutation in a New Cataract Rat Model
por: Shen, Jiawei, et al.
Publicado: (2023)

A crystallin mutant cataract with mineral deposits
por: Minogue, Peter J., et al.
Publicado: (2023)

Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts
por: Lu, Qingxian, et al.
Publicado: (2020)

p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency
por: Jara, Oscar, et al.
Publicado: (2020)

C-Terminal End of Aquaporin 0 Regulates Lens Gap Junction Channel Function
por: Varadaraj, Kulandaiappan, et al.
Publicado: (2019)

Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation
por: Minogue, Peter J., et al.
Publicado: (2022)

Lens Connexin Channels Have Differential Permeability to the Second Messenger cAMP
por: Valiunas, Virginijus, et al.
Publicado: (2019)

Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins
por: Kumari, Sindhu, et al.
Publicado: (2017)

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens
por: Delamere, Nicholas A., et al.
Publicado: (2020)

The Ciliary Muscle and Zonules of Zinn Modulate Lens Intracellular Hydrostatic Pressure Through Transient Receptor Potential Vanilloid Channels
por: Chen, Yadi, et al.
Publicado: (2019)

ErbBs in Lens Cell Fibrosis and Secondary Cataract
por: VanSlyke, Judy K., et al.
Publicado: (2023)

The Connexin46 Mutant, Cx46T19M, Causes Loss of Gap Junction Function and Alters Hemi-channel Gating
por: Tong, Jun-Jie, et al.
Publicado: (2014)

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery
por: Jiang, Jian, et al.
Publicado: (2018)

Changes in the Lipid Profile of Aqueous Humor From Diabetic Cataract Patients
por: Wang, Jiawei, et al.
Publicado: (2022)

Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0(ΔC/ΔC) Mice
por: Varadaraj, Kulandaiappan, et al.
Publicado: (2019)

Connections Between Connexins, Calcium, and Cataracts in the Lens
por: Gao, Junyuan, et al.
Publicado: (2004)

Early Onset of Age-Related Cataracts in Cystine/Glutamate Antiporter Knockout Mice
por: Martis, Renita Maria, et al.
Publicado: (2021)

Phase-Decorrelation Optical Coherence Tomography Measurement of Cold-Induced Nuclear Cataract
por: Blackburn, Brecken J., et al.
Publicado: (2023)

Establishing the influence of case complexity on the order of cataract lists: a cross-sectional survey
por: McLean, Keri, et al.
Publicado: (2021)

Deformations and Ruptures in Human Lenses With Cortical Cataract Subjected to Ex Vivo Simulated Accommodation
por: Michael, Ralph, et al.
Publicado: (2021)

Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts
por: Wei, Zongbo, et al.
Publicado: (2021)

Racial Disparities in Cataract Surgery Timeline and Intraocular Lens Selection: A Retrospective Study
por: Buscho, Seth E., et al.
Publicado: (2023)

Aldose Reductase Inhibition Prevents Development of Posterior Capsular Opacification in an In Vivo Model of Cataract Surgery
por: Zukin, Leonid M., et al.
Publicado: (2018)

Genotype, Age, Genetic Background, and Sex Influence Epha2-Related Cataract Development in Mice
por: Dave, Alpana, et al.
Publicado: (2021)

Aged Nrf2-Null Mice Develop All Major Types of Age-Related Cataracts
por: Rowan, Sheldon, et al.
Publicado: (2021)

Zebrafish (Danio rerio) Is an Economical and Efficient Animal Model for Screening Potential Anti-cataract Compounds
por: Liu, Chun-Fu, et al.
Publicado: (2022)

Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses
por: Li, Jiani, et al.
Publicado: (2022)

Anti-inflammatory treatment after cataract surgery in Sweden: changes in prescribing patterns from 2010 to 2017
por: Samadi, Behrad, et al.
Publicado: (2021)

TFEB-Mediated Lysosomal Restoration Alleviates High Glucose-Induced Cataracts Via Attenuating Oxidative Stress
por: Sun, Yan, et al.
Publicado: (2022)

SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation
por: Lian, Lili, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_g7obucl0qu0pga7nkgk1auv2kd