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Efficient access to N-trifluoroacetylated 2′-amino-2′-deoxyadenosine phosphoramidite for RNA solid-phase synthesis

ABSTRACT: Here, we present a robust synthetic route to a 2′-amino-2′-deoxyadenosine phosphoramidite building block for automated RNA solid-phase synthesis. The thus accessible 2′-amino-modified RNA finds applications in the evaluation of hydrogen-bond networks in folded RNA, such as riboswitches or...

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Detalles Bibliográficos
Autores principales: Falschlunger, Christoph, Micura, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534076/
https://www.ncbi.nlm.nih.gov/pubmed/31178603
http://dx.doi.org/10.1007/s00706-019-02390-x