Design and synthesis of novel pyrazolo[4,3-d]pyrimidines as potential therapeutic agents for acute lung injury

Four series of total 35 new pyrazolo[4,3-d]pyrimidine compounds were designed, synthesized and evaluated for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Among them, compound 4e was found to be the most potent inhibitor, which decreased the production of cytok...

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Detalles Bibliográficos
Autores principales: Wang, Bao Shi, Huang, Xin, Chen, Liu Zeng, Liu, Ming Ming, Shi, Jing Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534230/
https://www.ncbi.nlm.nih.gov/pubmed/31117832
http://dx.doi.org/10.1080/14756366.2019.1618291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534230/
https://www.ncbi.nlm.nih.gov/pubmed/31117832
http://dx.doi.org/10.1080/14756366.2019.1618291

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