Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review

BACKGROUND: The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment, while avoiding the risk of hepatotoxicity. OBJ...

Descripción completa

Detalles Bibliográficos
Autores principales: Toksvang, Linea Natalie, Schmidt, Magnus Strøh, Arup, Sofie, Larsen, Rikke Hebo, Frandsen, Thomas Leth, Schmiegelow, Kjeld, Rank, Cecilie Utke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534292/
https://www.ncbi.nlm.nih.gov/pubmed/31125338
http://dx.doi.org/10.1371/journal.pone.0212157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534292/
https://www.ncbi.nlm.nih.gov/pubmed/31125338
http://dx.doi.org/10.1371/journal.pone.0212157

Ejemplares similares