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Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: A systematic review

BACKGROUND: The recently established association between higher levels of DNA-incorporated thioguanine nucleotides and lower relapse risk in childhood acute lymphoblastic leukaemia (ALL) calls for reassessment of prolonged 6-thioguanine (6TG) treatment, while avoiding the risk of hepatotoxicity. OBJ...

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Detalles Bibliográficos
Autores principales:	Toksvang, Linea Natalie, Schmidt, Magnus Strøh, Arup, Sofie, Larsen, Rikke Hebo, Frandsen, Thomas Leth, Schmiegelow, Kjeld, Rank, Cecilie Utke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534292/ https://www.ncbi.nlm.nih.gov/pubmed/31125338 http://dx.doi.org/10.1371/journal.pone.0212157

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