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Mathematical modelling of cell migration: stiffness dependent jump rates result in durotaxis

Durotaxis, the phenomena where cells migrate up a gradient in substrate stiffness, remains poorly understood. It has been proposed that durotaxis results from the reinforcement of focal adhesions on stiff substrates. In this paper we formulate a mathematical model of single cell migration on elastic...

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Detalles Bibliográficos
Autores principales: Malik, Adam A., Gerlee, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534528/
https://www.ncbi.nlm.nih.gov/pubmed/30972438
http://dx.doi.org/10.1007/s00285-019-01344-5