MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes

Urokinase plasminogen activator receptor (uPAR) is upregulated in podocytes of glomerular diseases and crucially mediates podocyte injury through integrin β3 (ITGB3). We previously showed that the miR-30 family maintains podocyte structure and function by inhibiting injurious calcineurin signaling t...

Descripción completa

Detalles Bibliográficos
Autores principales: Lang, Yue, Zhao, Yue, Zheng, Chunxia, Lu, Yinghui, Wu, Junnan, Zhu, Xiaodong, Zhang, Mingchao, Yang, Fan, Xu, Xiaodong, Shi, Shaolin, Liu, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534572/
https://www.ncbi.nlm.nih.gov/pubmed/31127093
http://dx.doi.org/10.1038/s41419-019-1625-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534572/
https://www.ncbi.nlm.nih.gov/pubmed/31127093
http://dx.doi.org/10.1038/s41419-019-1625-y

Ejemplares similares