Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylat...

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Detalles Bibliográficos
Autores principales: Qian, Hongwu, Cao, Pingping, Hu, Miaohui, Gao, Shuai, Yan, Nieng, Gong, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534611/
https://www.ncbi.nlm.nih.gov/pubmed/31127104
http://dx.doi.org/10.1038/s41467-019-10234-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534611/
https://www.ncbi.nlm.nih.gov/pubmed/31127104
http://dx.doi.org/10.1038/s41467-019-10234-9

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