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RNA ligands activate the Machupo virus polymerase and guide promoter usage

Segmented negative-sense (SNS) RNA viruses initiate infection by delivering into cells a suite of genomic RNA segments, each sheathed by the viral nucleocapsid protein and bound by the RNA-dependent RNA-polymerase (RdRP). For the orthomyxovirus influenza and the bunyavirus La Crosse, the 5′ end of t...

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Detalles Bibliográficos
Autores principales: Pyle, Jesse D., Whelan, Sean P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535001/
https://www.ncbi.nlm.nih.gov/pubmed/31072925
http://dx.doi.org/10.1073/pnas.1900790116