Cargando…

Modulation of Coenzyme Q(10) content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging

Coenzyme Q(10) (CoQ(10)) is an endogenous lipophilic quinone, ubiquitous in biological membranes and endowed with antioxidant and bioenergetic properties, both crucial to the aging process. In fact, coenzyme Q(10) synthesis is known to decrease with age in different tissues including skin. Moreover,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marcheggiani, Fabio, Cirilli, Ilenia, Orlando, Patrick, Silvestri, Sonia, Vogelsang, Alexandra, Knott, Anja, Blatt, Thomas, Weise, Julia M., Tiano, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535058/ https://www.ncbi.nlm.nih.gov/pubmed/31076563 http://dx.doi.org/10.18632/aging.101926

Ejemplares similares

The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases
por: Friesen, Jon A, et al.
Publicado: (2004)

Pleiotropic effects of the HMG-CoA reductase inhibitors
por: Mihos, Christos G, et al.
Publicado: (2011)

Role of Coenzyme Q(10) in Health and Disease: An Update on the Last 10 Years (2010–2020)
por: Cirilli, Ilenia, et al.
Publicado: (2021)

Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors
por: Samizo, Shigeyoshi, et al.
Publicado: (2023)

Menaquinone 7 Stability of Formulations and Its Relationship with Purity Profile
por: Orlando, Patrick, et al.
Publicado: (2019)

The role of HMG-CoA reductase inhibition in endothelial dysfunction and inflammation
por: Gelosa, Paolo, et al.
Publicado: (2007)

Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
por: Noël, Martin, et al.
Publicado: (2004)

Structural and functional characterization of HMG-COA reductase from Artemisia annua
por: Kiran, Usha, et al.
Publicado: (2010)

Transcription of the three HMG-CoA reductase genes of Mucor circinelloides
por: Nagy, Gábor, et al.
Publicado: (2014)

Functional Implications of HMG-CoA Reductase Inhibition on Glucose Metabolism
por: Han, Ki Hoon
Publicado: (2018)

Chronic Onset Form of Anti-HMG-CoA Reductase Myopathy
por: Lorenzo-Villalba, Noel, et al.
Publicado: (2021)

Eupatilin Alleviates Hyperlipidemia in Mice by Inhibiting HMG-CoA Reductase
por: Kim, Kyung-Joo, et al.
Publicado: (2023)

Are Point Mutations in HMG-CoA Reductases (Hmg1 and Hmg2) a Step towards Azole Resistance in Aspergillus fumigatus?
por: Gonzalez-Jimenez, Irene, et al.
Publicado: (2021)

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity
por: Giannubilo, Stefano Raffaele, et al.
Publicado: (2018)

The Protective Role of Bioactive Quinones in Stress-induced Senescence Phenotype of Endothelial Cells Exposed to Cigarette Smoke Extract
por: Cirilli, Ilenia, et al.
Publicado: (2020)

Carboxylative efficacy of trans and cis MK7 and comparison with other vitamin K isomers
por: Cirilli, Ilenia, et al.
Publicado: (2022)

Selection of HMG-coenzyme A reductase inhibitors using multiattribute scoring tool
por: Ramli, Azuana, et al.
Publicado: (2012)

HMG-Coenzyme A Reductase as a Drug Target for the Prevention of Ankylosing Spondylitis
por: Zhong, Zhenyu, et al.
Publicado: (2021)

7-Acetoxyhorminone from Salvia multicaulis Vahl. as Promising Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase
por: Yigitkan, Serkan, et al.
Publicado: (2022)

Anti-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Anti-HMG CoA) Myopathy With Cardiac Involvement: Presentation, Diagnosis, and Management
por: Liu, Lisa, et al.
Publicado: (2022)

Modulation of Oxidative Status by Normoxia and Hypoxia on Cultures of Human Dermal Fibroblasts: How Does It Affect Cell Aging?
por: Damiani, Elisabetta, et al.
Publicado: (2018)

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes
por: Orlando, Patrick, et al.
Publicado: (2018)

CoQ(10)Phytosomes Improve Cellular Ubiquinone Uptake in Skeletal Muscle Cells: An Ex Vivo Study Using CoQ(10)-Enriched Low-Density Lipoproteins Obtained in a Randomized Crossover Study
por: Marcheggiani, Fabio, et al.
Publicado: (2023)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
por: Würtz, Peter, et al.
Publicado: (2016)

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
por: Schumacher, Marc M, et al.
Publicado: (2015)

The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
por: Alsehli, Ahmed M., et al.
Publicado: (2022)

N-Acetyl cysteine ameliorates hyperglycemia-induced cardiomyocyte toxicity by improving mitochondrial energetics and enhancing endogenous Coenzyme Q(9/10) levels
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2019)

Degradation of HMG-CoA reductase-induced membranes in the fission yeast, Schizosaccharomyces pombe
Publicado: (1995)

Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer
por: Solanki, Abhishek A, et al.
Publicado: (2011)

Lepidopteran HMG-CoA reductase is a potential selective target for pest control
por: Li, Yuan-mei, et al.
Publicado: (2017)

HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
por: Lacher, Sonja M, et al.
Publicado: (2017)

An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
por: Gesto, Diana S., et al.
Publicado: (2020)

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
por: Kettunen, Johannes, et al.
Publicado: (2019)

Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
por: Bose, Sucharita, et al.
Publicado: (2023)

Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects
por: Orlando, Patrick, et al.
Publicado: (2020)

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
por: Jiang, Shi-You, et al.
Publicado: (2018)

Coenzyme Q(10) Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
por: Dludla, Phiwayinkosi V., et al.
Publicado: (2020)

HMG CoA reductase inhibitors (statins) to treat Epstein–Barr virus-driven lymphoma
por: Cohen, J I
Publicado: (2005)

Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast
Publicado: (1994)

Association between Use of HMG CoA Reductase Inhibitors and Mortality in HIV-Infected Patients
por: Moore, Richard D., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6ikacofa0i8lg36i9n1sq8nj8i