Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

BACKGROUND: Microglia-mediated neuroinflammation is important in Alzheimer’s disease (AD) pathogenesis. Extracellular deposition of β-amyloid (Aβ), a major pathological hallmark of AD, can induce microglia activation. Adiponectin (APN), an adipocyte-derived adipokine, exerts anti-inflammatory effect...

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Detalles Bibliográficos
Autores principales: Jian, Min, Kwan, Jason Shing-Cheong, Bunting, Myriam, Ng, Roy Chun-Laam, Chan, Koon Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535190/
https://www.ncbi.nlm.nih.gov/pubmed/31128596
http://dx.doi.org/10.1186/s12974-019-1492-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535190/
https://www.ncbi.nlm.nih.gov/pubmed/31128596
http://dx.doi.org/10.1186/s12974-019-1492-6

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