Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience

Tofacitinib is an oral small molecule directed against the JAK/STAT pathway, blocking the inflammatory cascade. Oral formulation of tofacitinib has recently been approved for the treatment of patients with moderate–severe ulcerative colitis. Its efficacy and safety have been demonstrated in three ph...

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Detalles Bibliográficos
Autores principales: D’Amico, Ferdinando, Parigi, Tommaso Lorenzo, Fiorino, Gionata, Peyrin-Biroulet, Laurent, Danese, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535722/
https://www.ncbi.nlm.nih.gov/pubmed/31205486
http://dx.doi.org/10.1177/1756284819848631
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author D’Amico, Ferdinando
Parigi, Tommaso Lorenzo
Fiorino, Gionata
Peyrin-Biroulet, Laurent
Danese, Silvio
author_facet D’Amico, Ferdinando
Parigi, Tommaso Lorenzo
Fiorino, Gionata
Peyrin-Biroulet, Laurent
Danese, Silvio
author_sort D’Amico, Ferdinando
collection PubMed
description Tofacitinib is an oral small molecule directed against the JAK/STAT pathway, blocking the inflammatory cascade. Oral formulation of tofacitinib has recently been approved for the treatment of patients with moderate–severe ulcerative colitis. Its efficacy and safety have been demonstrated in three phase III clinical trials and confirmed by promising real-life data. The purpose of this review is to summarize the available evidence on the efficacy and safety of tofacitinib and to define its role and position in the treatment algorithms for patients with ulcerative colitis.
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spelling pubmed-65357222019-06-14 Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience D’Amico, Ferdinando Parigi, Tommaso Lorenzo Fiorino, Gionata Peyrin-Biroulet, Laurent Danese, Silvio Therap Adv Gastroenterol Review Tofacitinib is an oral small molecule directed against the JAK/STAT pathway, blocking the inflammatory cascade. Oral formulation of tofacitinib has recently been approved for the treatment of patients with moderate–severe ulcerative colitis. Its efficacy and safety have been demonstrated in three phase III clinical trials and confirmed by promising real-life data. The purpose of this review is to summarize the available evidence on the efficacy and safety of tofacitinib and to define its role and position in the treatment algorithms for patients with ulcerative colitis. SAGE Publications 2019-05-16 /pmc/articles/PMC6535722/ /pubmed/31205486 http://dx.doi.org/10.1177/1756284819848631 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
D’Amico, Ferdinando
Parigi, Tommaso Lorenzo
Fiorino, Gionata
Peyrin-Biroulet, Laurent
Danese, Silvio
Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title_full Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title_fullStr Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title_full_unstemmed Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title_short Tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
title_sort tofacitinib in the treatment of ulcerative colitis: efficacy and safety from clinical trials to real-world experience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535722/
https://www.ncbi.nlm.nih.gov/pubmed/31205486
http://dx.doi.org/10.1177/1756284819848631
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