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Mechanistic Basis for Ribosomal Peptide Backbone Modifications

[Image: see text] YcaO enzymes are known to catalyze the ATP-dependent formation of azoline heterocycles, thioamides, and (macro)lactamidines on peptide substrates. These enzymes are found in multiple biosynthetic pathways, including those for several different classes of ribosomally synthesized and...

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Detalles Bibliográficos
Autores principales: Dong, Shi-Hui, Liu, Andi, Mahanta, Nilkamal, Mitchell, Douglas A., Nair, Satish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535971/
https://www.ncbi.nlm.nih.gov/pubmed/31139720
http://dx.doi.org/10.1021/acscentsci.9b00124