Cargando…

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

OBJECTIVES: Prostate cancer, after the phase of androgen dependence, may progress to the castration‐resistant prostate cancer (CRPC) stage, with resistance to standard therapies. Vitamin E‐derived tocotrienols (TTs) possess a significant antitumour activity. Here, we evaluated the anti‐cancer proper...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fontana, Fabrizio, Moretti, Roberta Manuela, Raimondi, Michela, Marzagalli, Monica, Beretta, Giangiacomo, Procacci, Patrizia, Sartori, Patrizia, Montagnani Marelli, Marina, Limonta, Patrizia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536411/ https://www.ncbi.nlm.nih.gov/pubmed/30719778 http://dx.doi.org/10.1111/cpr.12576

Ejemplares similares

Ca(2+) overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells
por: Raimondi, Michela, et al.
Publicado: (2021)

Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells
por: Montagnani Marelli, Marina, et al.
Publicado: (2016)

Targeting melanoma stem cells with the Vitamin E derivative δ-tocotrienol
por: Marzagalli, Monica, et al.
Publicado: (2018)

Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds
por: Limonta, Patrizia, et al.
Publicado: (2019)

δ‐Tocotrienol sensitizes and re‐sensitizes ovarian cancer cells to cisplatin via induction of G1 phase cell cycle arrest and ROS/MAPK‐mediated apoptosis
por: Fontana, Fabrizio, et al.
Publicado: (2021)

Gonadotropin-Releasing Hormone Receptors in Prostate Cancer: Molecular Aspects and Biological Functions
por: Fontana, Fabrizio, et al.
Publicado: (2020)

Estrogen Receptor β in Melanoma: From Molecular Insights to Potential Clinical Utility
por: Marzagalli, Monica, et al.
Publicado: (2016)

Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells
por: Montagnani Marelli, Marina, et al.
Publicado: (2023)

Cancer Stem Cells—Key Players in Tumor Relapse
por: Marzagalli, Monica, et al.
Publicado: (2021)

Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for δ-Tocotrienol
por: Fontana, Fabrizio, et al.
Publicado: (2022)

Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells
por: Cristofani, Riccardo, et al.
Publicado: (2018)

Estrogen Receptor β Agonists Differentially Affect the Growth of Human Melanoma Cell Lines
por: Marzagalli, Monica, et al.
Publicado: (2015)

Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets
por: Fontana, Fabrizio, et al.
Publicado: (2020)

Epithelial-To-Mesenchymal Transition Markers and CD44 Isoforms Are Differently Expressed in 2D and 3D Cell Cultures of Prostate Cancer Cells
por: Fontana, Fabrizio, et al.
Publicado: (2019)

Three-Dimensional Cell Cultures as an In Vitro Tool for Prostate Cancer Modeling and Drug Discovery
por: Fontana, Fabrizio, et al.
Publicado: (2020)

Adipocyte-Derived Extracellular Vesicles Promote Prostate Cancer Cell Aggressiveness by Enabling Multiple Phenotypic and Metabolic Changes
por: Fontana, Fabrizio, et al.
Publicado: (2022)

Gonadotropin-Releasing Hormone Agonists Sensitize, and Resensitize, Prostate Cancer Cells to Docetaxel in a p53-Dependent Manner
por: Moretti, Roberta M., et al.
Publicado: (2014)

Beneficial effects of δ-tocotrienol against oxidative stress in osteoblastic cells: studies on the mechanisms of action
por: Casati, Lavinia, et al.
Publicado: (2019)

In Vitro 3D Cultures to Model the Tumor Microenvironment
por: Fontana, Fabrizio, et al.
Publicado: (2021)

Melanoma Stem Cells Educate Neutrophils to Support Cancer Progression
por: Anselmi, Martina, et al.
Publicado: (2022)

Apoptosis-mediated anticancer activity in prostate cancer cells of a chestnut honey (Castanea sativa L.) quinoline–pyrrolidine gamma-lactam alkaloid
por: Beretta, Giangiacomo, et al.
Publicado: (2021)

Dissecting the Hormonal Signaling Landscape in Castration-Resistant Prostate Cancer
por: Fontana, Fabrizio, et al.
Publicado: (2021)

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
por: Comitato, Raffaella, et al.
Publicado: (2016)

γ-Tocotrienol Induces Paraptosis-Like Cell Death in Human Colon Carcinoma SW620 Cells
por: Zhang, Jing-Shu, et al.
Publicado: (2013)

Molecular Mechanisms of Cancer Drug Resistance: Emerging Biomarkers and Promising Targets to Overcome Tumor Progression
por: Fontana, Fabrizio, et al.
Publicado: (2022)

Unraveling the Peculiar Features of Mitochondrial Metabolism and Dynamics in Prostate Cancer
por: Fontana, Fabrizio, et al.
Publicado: (2023)

Adipocytes reprogram prostate cancer stem cell machinery
por: Fontana, Fabrizio, et al.
Publicado: (2023)

Release of Ca(2+) from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells
por: Yoon, Mi Jin, et al.
Publicado: (2014)

Tumor–Stroma Cross-Talk in Human Pancreatic Ductal Adenocarcinoma: A Focus on the Effect of the Extracellular Matrix on Tumor Cell Phenotype and Invasive Potential
por: Procacci, Patrizia, et al.
Publicado: (2018)

Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol
por: Nakatani, Yusuke, et al.
Publicado: (2022)

A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress
por: Ma, Mengjiao, et al.
Publicado: (2023)

Targeting the hallmarks of cancer with therapy-induced endoplasmic reticulum (ER) stress
por: Garg, Abhishek D, et al.
Publicado: (2014)

Activity of Experimental Mouthwashes and Gels Containing DNA-RNA and Bioactive Molecules against the Oxidative Stress of Oral Soft Tissues: The Importance of Formulations. A Bioreactor-Based Reconstituted Human Oral Epithelium Model
por: Ionescu, Andrei C., et al.
Publicado: (2021)

Heterologous and cross-species tropism of cancer-derived extracellular vesicles
por: Garofalo, Mariangela, et al.
Publicado: (2019)

Syntaxin 8 and the Endoplasmic Reticulum Processing of ΔF508-CFTR
por: Sabirzhanova, Inna, et al.
Publicado: (2018)

Chalcomoracin inhibits cell proliferation and increases sensitivity to radiotherapy in human non-small cell lung cancer cells via inducing endoplasmic reticulum stress-mediated paraptosis
por: Zhang, Shi-rong, et al.
Publicado: (2020)

Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response
por: Pang, Kok-Lun, et al.
Publicado: (2023)

The Antagonism of the Prokineticin System Counteracts Bortezomib Induced Side Effects: Focus on Mood Alterations
por: Amodeo, Giada, et al.
Publicado: (2021)

Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca(2+) Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum
por: Yokoi, Kenta, et al.
Publicado: (2022)

Ca(2+)-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane
por: Haßdenteufel, Sarah, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_c459f9kt9ps92j7s3m8os4mf65