PD‐1/PD‐L1 blockade rescue exhausted CD8+ T cells in gastrointestinal stromal tumours via the PI3K/Akt/mTOR signalling pathway

OBJECTIVES: Although targeted therapy has revolutionized the treatment of gastrointestinal stromal tumours (GIST), it is almost never curative in GIST, and resistance commonly develops. One potential strategy is to combine targeted therapy with immunotherapy. MATERIALS AND METHODS: We first studied...

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Detalles Bibliográficos
Autores principales: Zhao, Rui, Song, Yinghan, Wang, Yong, Huang, Yuqian, Li, Zhigui, Cui, Yaping, Yi, Mengshi, Xia, Lin, Zhuang, Wen, Wu, Xiaoting, Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536456/
https://www.ncbi.nlm.nih.gov/pubmed/30714229
http://dx.doi.org/10.1111/cpr.12571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536456/
https://www.ncbi.nlm.nih.gov/pubmed/30714229
http://dx.doi.org/10.1111/cpr.12571

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