Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal

Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascular complications of diabetes where increased reactive glycating agent, methylglyoxal (MG), is involved. We assessed if increased MG glycation induced proteotoxic stress, identifying related metabolic...

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Detalles Bibliográficos
Autores principales: Irshad, Zehra, Xue, Mingzhan, Ashour, Amal, Larkin, James R., Thornalley, Paul J., Rabbani, Naila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536510/
https://www.ncbi.nlm.nih.gov/pubmed/31133647
http://dx.doi.org/10.1038/s41598-019-44358-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536510/
https://www.ncbi.nlm.nih.gov/pubmed/31133647
http://dx.doi.org/10.1038/s41598-019-44358-1

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