Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells

Introduction: Increased iron content in cancer cells is associated with resistance to chemotherapy. Recent studies have demonstrated that estrogen (E(2)) suppresses hepcidin synthesis and enhances intracellular iron efflux. Herein, we investigated whether E(2)-driven intracellular iron efflux render...

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Detalles Bibliográficos
Autores principales: Bajbouj, Khuloud, Shafarin, Jasmin, Hamad, Mawieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536718/
https://www.ncbi.nlm.nih.gov/pubmed/31213891
http://dx.doi.org/10.2147/CMAR.S204852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536718/
https://www.ncbi.nlm.nih.gov/pubmed/31213891
http://dx.doi.org/10.2147/CMAR.S204852

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