New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation

Chronic obstructive pulmonary disease (COPD) has become one of the major public health problems worldwide due to its high morbidity and mortality. Up until now, COPD is still under-diagnosed and under-treated, especially for mild or moderate patients. It is widely accepted that the majority of patie...

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Autores principales: Sun, Yilan, Zhou, Jianying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536809/
https://www.ncbi.nlm.nih.gov/pubmed/31213792
http://dx.doi.org/10.2147/COPD.S205382
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author Sun, Yilan
Zhou, Jianying
author_facet Sun, Yilan
Zhou, Jianying
author_sort Sun, Yilan
collection PubMed
description Chronic obstructive pulmonary disease (COPD) has become one of the major public health problems worldwide due to its high morbidity and mortality. Up until now, COPD is still under-diagnosed and under-treated, especially for mild or moderate patients. It is widely accepted that the majority of patients with COPD are in the early stages, yet this subpopulation is underestimated. In recent years, growing evidence indicates that substantial physiological and clinical abnormalities exist in patients with mild COPD compared with healthy controls. Furthermore, recent studies suggest that pharmacologic intervention in early COPD has the potential to alter clinical outcomes. The main objective of this review is to summarize recent research regarding the heterogeneous pathophysiology, clinical features, and treatment of mild and moderate COPD. We also discuss promising markers of disease progression, which may contribute to the development of precision medicine in early COPD.
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spelling pubmed-65368092019-06-18 New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation Sun, Yilan Zhou, Jianying Int J Chron Obstruct Pulmon Dis Review Chronic obstructive pulmonary disease (COPD) has become one of the major public health problems worldwide due to its high morbidity and mortality. Up until now, COPD is still under-diagnosed and under-treated, especially for mild or moderate patients. It is widely accepted that the majority of patients with COPD are in the early stages, yet this subpopulation is underestimated. In recent years, growing evidence indicates that substantial physiological and clinical abnormalities exist in patients with mild COPD compared with healthy controls. Furthermore, recent studies suggest that pharmacologic intervention in early COPD has the potential to alter clinical outcomes. The main objective of this review is to summarize recent research regarding the heterogeneous pathophysiology, clinical features, and treatment of mild and moderate COPD. We also discuss promising markers of disease progression, which may contribute to the development of precision medicine in early COPD. Dove 2019-05-23 /pmc/articles/PMC6536809/ /pubmed/31213792 http://dx.doi.org/10.2147/COPD.S205382 Text en © 2019 Sun and Zhou. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Sun, Yilan
Zhou, Jianying
New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title_full New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title_fullStr New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title_full_unstemmed New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title_short New insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
title_sort new insights into early intervention of chronic obstructive pulmonary disease with mild airflow limitation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536809/
https://www.ncbi.nlm.nih.gov/pubmed/31213792
http://dx.doi.org/10.2147/COPD.S205382
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