ET(A)R and protein kinase A pathway mediate ET-1 sensitization of TRPA1 channel: A molecular mechanism of ET-1-induced mechanical hyperalgesia

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that has been widely known as a pain mediator involved in various pain states. Evidence indicates that ET-1 sensitizes transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in vivo. But the molecular mechanisms still rem...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaoli, Tai, Yan, He, Dongwei, Liu, Boyu, Wang, Chuan, Shao, Xiaomei, Jordt, Sven-Eric, Liu, Boyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537062/
https://www.ncbi.nlm.nih.gov/pubmed/30990108
http://dx.doi.org/10.1177/1744806919842473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537062/
https://www.ncbi.nlm.nih.gov/pubmed/30990108
http://dx.doi.org/10.1177/1744806919842473

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