HIV-induced matrix metalloproteinase-9 activation through mitogen-activated protein kinase signalling promotes HSV-1 cell-to-cell spread in oral epithelial cells

We have shown that cell-free HIV-1 and viral proteins tat and gp120 activate mitogen-activated protein kinases (MAPKs) in tonsil epithelial cells, disrupting their tight and adherens junctions. This causes liberation of the HSV-1 receptor nectin-1 from assembled adherens junctions, leading to promot...

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Detalles Bibliográficos
Autores principales: Sufiawati, Irna, Tugizov, Sharof M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537617/
https://www.ncbi.nlm.nih.gov/pubmed/29775175
http://dx.doi.org/10.1099/jgv.0.001075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537617/
https://www.ncbi.nlm.nih.gov/pubmed/29775175
http://dx.doi.org/10.1099/jgv.0.001075

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