Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

Tau protein aggregation into neurofibrillary tangles in the central nervous system contributes to the etiology of certain neurodegenerative disorders, including Alzheimer’s disease (AD). Though the mechanism of tau destabilization is not fully understood yet, tau protein has been found to be hyperph...

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Detalles Bibliográficos
Autores principales: Barthélemy, Nicolas R., Mallipeddi, Nipun, Moiseyev, Paul, Sato, Chihiro, Bateman, Randall J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537657/
https://www.ncbi.nlm.nih.gov/pubmed/31178717
http://dx.doi.org/10.3389/fnagi.2019.00121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537657/
https://www.ncbi.nlm.nih.gov/pubmed/31178717
http://dx.doi.org/10.3389/fnagi.2019.00121

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