Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma

New anticancer agents are highly needed to overcome cancer cell resistance. A novel series of pyrimidine pyrazoline-anthracene derivatives (PPADs) (4a-t) were designed and synthesised. The anti-liver cancer activity of all compounds was screened in vitro against two hepatocellular carcinoma (HCC) ce...

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Detalles Bibliográficos
Autores principales: Ahmed, Naglaa Mohamed, Youns, Mahmoud, Soltan, Moustafa Khames, Said, Ahmed Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537702/
https://www.ncbi.nlm.nih.gov/pubmed/31117890
http://dx.doi.org/10.1080/14756366.2019.1612889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537702/
https://www.ncbi.nlm.nih.gov/pubmed/31117890
http://dx.doi.org/10.1080/14756366.2019.1612889

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