Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Advanced age and the APOE ε4 allele are the two biggest risk factors for Alzheimer’s disease (AD) and declining cognitive function. We describe a universal gauge to measure molecular brain age using transcriptome analysis of four human postmortem cohorts (n = 673, ages 25–97) free of neurological di...

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Detalles Bibliográficos
Autores principales: Glorioso, Christin A, Pfenning, Andreas R, Lee, Sam S, Bennett, David A, Sibille, Etienne L, Kellis, Manolis, Guarente, Leonard P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537750/
https://www.ncbi.nlm.nih.gov/pubmed/31133613
http://dx.doi.org/10.26508/lsa.201900303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537750/
https://www.ncbi.nlm.nih.gov/pubmed/31133613
http://dx.doi.org/10.26508/lsa.201900303

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