Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

Petite Integration Factor 1 (PIF1) is a multifunctional helicase present in nuclei and mitochondria. PIF1 knock out (KO) mice exhibit accelerated weight gain and decreased wheel running on a normal chow diet. In the current study, we investigated whether Pif1 ablation alters whole body metabolism in...

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Detalles Bibliográficos
Autores principales: Belmonte, Frances R., Dedousis, Nikolaos, Sipula, Ian, Desai, Nikita A., Singhi, Aatur D., Chu, Yanxia, Zhang, Yingze, Bannwarth, Sylvie, Paquis-Flucklinger, Véronique, Harrington, Lea, Shiva, Sruti, Jurczak, Michael J., O’Doherty, Robert M., Kaufman, Brett A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538152/
https://www.ncbi.nlm.nih.gov/pubmed/31136580
http://dx.doi.org/10.1371/journal.pone.0203101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538152/
https://www.ncbi.nlm.nih.gov/pubmed/31136580
http://dx.doi.org/10.1371/journal.pone.0203101

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