Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologically based toxicokinetic (PBTK) model to relate in...

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Detalles Bibliográficos
Autores principales: Honda, Gregory S., Pearce, Robert G., Pham, Ly L., Setzer, R. W., Wetmore, Barbara A., Sipes, Nisha S., Gilbert, Jon, Franz, Briana, Thomas, Russell S., Wambaugh, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538186/
https://www.ncbi.nlm.nih.gov/pubmed/31136631
http://dx.doi.org/10.1371/journal.pone.0217564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538186/
https://www.ncbi.nlm.nih.gov/pubmed/31136631
http://dx.doi.org/10.1371/journal.pone.0217564

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