Cargando…

Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions

Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the use of a high-throughput, physiologically based toxicokinetic (PBTK) model to relate in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Honda, Gregory S., Pearce, Robert G., Pham, Ly L., Setzer, R. W., Wetmore, Barbara A., Sipes, Nisha S., Gilbert, Jon, Franz, Briana, Thomas, Russell S., Wambaugh, John F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538186/ https://www.ncbi.nlm.nih.gov/pubmed/31136631 http://dx.doi.org/10.1371/journal.pone.0217564

Ejemplares similares

Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues
por: Chang, Xiaoqing, et al.
Publicado: (2022)

Evaluation and Optimization of Pharmacokinetic Models for in Vitro to in Vivo Extrapolation of Estrogenic Activity for Environmental Chemicals
por: Casey, Warren M., et al.
Publicado: (2018)

Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals
por: Klaren, William D, et al.
Publicado: (2019)

In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity
por: Müller, Fabrice A., et al.
Publicado: (2023)

Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation
por: Moreau, Marjory, et al.
Publicado: (2022)

A Computational Workflow for Probabilistic Quantitative in Vitro to in Vivo Extrapolation
por: McNally, Kevin, et al.
Publicado: (2018)

Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
por: Hines, David E., et al.
Publicado: (2022)

Evidence, eminence and extrapolation
por: Hlavin, Gerald, et al.
Publicado: (2016)

Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals
por: Linakis, Matthew W., et al.
Publicado: (2020)

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
por: Najjar, Abdulkarim, et al.
Publicado: (2022)

How to Test Your Assumptions
por: Fjeld, Jon
Publicado: (2018)

Metabolic profiling and in vitro-in vivo extrapolation of furathiocarb in mammalian hepatic microsomes
por: Abass, Khaled, et al.
Publicado: (2022)

Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis
por: McLean, Polly, et al.
Publicado: (2023)

Analysis of the Effects of Cell Stress and Cytotoxicity onIn Vitro Assay Activity Across a Diverse Chemical and Assay Space
por: Judson, Richard, et al.
Publicado: (2016)

Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
por: Wetmore, Barbara A., et al.
Publicado: (2015)

One extraction tool for in vitro-in vivo extrapolation? SPME-based metabolomics of in vitro 2D, 3D, and in vivo mouse melanoma models
por: Jaroch, Karol, et al.
Publicado: (2021)

Ex Vivo Antioxidant Capacities of Fruit and Vegetable Juices. Potential In Vivo Extrapolation
por: Matute, Alexis, et al.
Publicado: (2021)

The Parametrized Extrapolator
por: Spenko, Kristof
Publicado: (2021)

Measured and Modeled Toxicokinetics in Cultured Fish Cells and Application to In Vitro - In Vivo Toxicity Extrapolation
por: Stadnicka-Michalak, Julita, et al.
Publicado: (2014)

New approach methodologies: A quantitative in vitro to in vivo extrapolation case study with PFASs
por: Fragki, Styliani, et al.
Publicado: (2023)

Advancing internal exposure and physiologically-based toxicokinetic modeling for 21st-century risk assessments
por: Cohen Hubal, Elaine A., et al.
Publicado: (2018)

Challenging the assumptions
por: Schmidt, CW
Publicado: (2000)

Questioning Assumptions
por: Poodry, Clifton A., et al.
Publicado: (2018)

Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
por: Yoon, Miyoung, et al.
Publicado: (2016)

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition
por: Murata, Yukiko, et al.
Publicado: (2022)

Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition
por: Yamazaki, Shinji, et al.
Publicado: (2021)

Evaluation of Inhalation Exposures and Potential Health Impacts of Ingredient Mixtures Using in vitro to in vivo Extrapolation
por: Zhang, Jingjie, et al.
Publicado: (2022)

Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling
por: Kim, Min-Chang, et al.
Publicado: (2022)

Extrapolating from acute to chronic toxicity in vitro
por: Macko, Peter, et al.
Publicado: (2021)

Extrapolation theory with applications
por: Jawerth, Bjorn, et al.
Publicado: (1991)

Extrapolation of carcinogenesis data
por: Lepkowski, Wil
Publicado: (1978)

Difference methods and their extrapolations
por: Marchuk, Yuri Ivanovich, et al.
Publicado: (1983)

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation
por: Algharably, Engi Abdelhady, et al.
Publicado: (2023)

Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling
por: Choi, Go-Wun, et al.
Publicado: (2019)

In Vitro‐to‐In Vivo Extrapolation of Transporter Inhibition Data for Drugs Approved by the US Food and Drug Administration in 2018
por: Yu, Jingjing, et al.
Publicado: (2020)

In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned
por: Algharably, Engi Abdelhady, et al.
Publicado: (2022)

Corrigendum to: Physiologically‐based pharmacokinetic modeling to evaluate in vitro‐to‐in vivo extrapolation for intestinal P‐glycoprotein inhibition
por: Yamazaki, Shinji, et al.
Publicado: (2022)

A BOLD Assumption
por: Vanzetta, Ivo, et al.
Publicado: (2010)

The Intentional Selection Assumption
por: Colantonio, Joseph, et al.
Publicado: (2021)

Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency
por: McAdams, David, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_se2p1el8ct9k6k356rls5db5pf