Computational determination of hERG-related cardiotoxicity of drug candidates

BACKGROUND: Drug candidates often cause an unwanted blockage of the potassium ion channel of the human ether-a-go-go-related gene (hERG). The blockage leads to long QT syndrome (LQTS), which is a severe life-threatening cardiac side effect. Therefore, a virtual screening method to predict drug-induc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hyang-Mi, Yu, Myeong-Sang, Kazmi, Sayada Reemsha, Oh, Seong Yun, Rhee, Ki-Hyeong, Bae, Myung-Ae, Lee, Byung Ho, Shin, Dae-Seop, Oh, Kwang-Seok, Ceong, Hyithaek, Lee, Donghyun, Na, Dokyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538553/
https://www.ncbi.nlm.nih.gov/pubmed/31138104
http://dx.doi.org/10.1186/s12859-019-2814-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538553/
https://www.ncbi.nlm.nih.gov/pubmed/31138104
http://dx.doi.org/10.1186/s12859-019-2814-5

Ejemplares similares