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Computational determination of hERG-related cardiotoxicity of drug candidates

BACKGROUND: Drug candidates often cause an unwanted blockage of the potassium ion channel of the human ether-a-go-go-related gene (hERG). The blockage leads to long QT syndrome (LQTS), which is a severe life-threatening cardiac side effect. Therefore, a virtual screening method to predict drug-induc...

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Detalles Bibliográficos
Autores principales:	Lee, Hyang-Mi, Yu, Myeong-Sang, Kazmi, Sayada Reemsha, Oh, Seong Yun, Rhee, Ki-Hyeong, Bae, Myung-Ae, Lee, Byung Ho, Shin, Dae-Seop, Oh, Kwang-Seok, Ceong, Hyithaek, Lee, Donghyun, Na, Dokyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538553/ https://www.ncbi.nlm.nih.gov/pubmed/31138104 http://dx.doi.org/10.1186/s12859-019-2814-5

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