First-in-human phase 1 study of novel dUTPase inhibitor TAS-114 in combination with S-1 in Japanese patients with advanced solid tumors

Background This first-in-human phase 1 study assessed the safety of TAS-114, a novel deoxyuridine triphosphatase inhibitor, combined with S-1 to determine its maximum tolerated dose (MTD) and recommended dose (RD). Methods In this dose-escalation study with a 3 + 3 design, TAS-114 and S-1 were concu...

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Detalles Bibliográficos
Autores principales: Doi, Toshihiko, Yoh, Kiyotaka, Shitara, Kohei, Takahashi, Hideaki, Ueno, Makoto, Kobayashi, Satoshi, Morimoto, Manabu, Okusaka, Takuji, Ueno, Hideki, Morizane, Chigusa, Okano, Naohiro, Nagashima, Fumio, Furuse, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538570/
https://www.ncbi.nlm.nih.gov/pubmed/30511200
http://dx.doi.org/10.1007/s10637-018-0697-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538570/
https://www.ncbi.nlm.nih.gov/pubmed/30511200
http://dx.doi.org/10.1007/s10637-018-0697-3

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