Cargando…

Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy-dependent manner

Hepatocellular carcinoma (HCC) is the one of the most common cancers worldwide. Because the side effects of current treatments are severe, new effective therapeutic strategies are urgently required. Pterostilbene (PT), a natural analogue of resveratrol, has diverse pharmacologic activities, includin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Chen-Lin, Yang, Shun-Fa, Hung, Tung-Wei, Lin, Chia-Liang, Hsieh, Yi-Hsien, Chiou, Hui-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538697/ https://www.ncbi.nlm.nih.gov/pubmed/31138785 http://dx.doi.org/10.1038/s41419-019-1639-5

Ejemplares similares

Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury
por: Tang, Yong-Jing, et al.
Publicado: (2020)

Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells
por: Teng, Y, et al.
Publicado: (2014)

Ferulic Acid, Pterostilbene, and Tyrosol Protect the Heart from ER-Stress-Induced Injury by Activating SIRT1-Dependent Deacetylation of eIF2α
por: Monceaux, Kévin, et al.
Publicado: (2022)

Protodioscin Induces Mitochondrial Apoptosis of Human Hepatocellular Carcinoma Cells Through Eliciting ER Stress-Mediated IP3R Targeting Mfn1/Bak Expression
por: Yu, Chen-Lin, et al.
Publicado: (2022)

Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner
por: Li, Jie, et al.
Publicado: (2020)

Pterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions
por: Tzeng, Wen-Sheng, et al.
Publicado: (2021)

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
por: Goyette, Jesse, et al.
Publicado: (2022)

Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells
por: Hsieh, Ming-Ju, et al.
Publicado: (2012)

Corrigendum to “Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells”
por: Hsieh, Ming-Ju, et al.
Publicado: (2017)

Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases
por: Chen, Rong-Jane, et al.
Publicado: (2016)

Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo
por: Hsieh, Chia-Ling, et al.
Publicado: (2022)

Anticancer Activity of Pterostilbene in Human Ovarian Cancer Cell Lines
por: Pei, Hui-lin, et al.
Publicado: (2017)

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant
por: Eytan, Karin, et al.
Publicado: (2022)

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α
por: Novoa, Isabel, et al.
Publicado: (2001)

Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells
por: Ying, Tsung-Ho, et al.
Publicado: (2016)

Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells
por: Hsu, Yi-Hao, et al.
Publicado: (2020)

Inhibition of EIF2α Dephosphorylation Decreases Cell Viability and Synergizes with Standard-of-Care Chemotherapeutics in Head and Neck Squamous Cell Carcinoma
por: Cyran, Anna M., et al.
Publicado: (2023)

Dehydroandrographolide, an iNOS inhibitor, extracted from from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells
por: Hsieh, Ming-Ju, et al.
Publicado: (2015)

Correction: Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells
por: Hsieh, Ming-Ju, et al.
Publicado: (2017)

Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner
por: Wu, Yang, et al.
Publicado: (2023)

Enhancement of Anticancer Potential of Pterostilbene Derivative by Chalcone Hybridization
por: Tang, Kai-Wei, et al.
Publicado: (2021)

Pterostilbene Simultaneously Induced G0/G1-Phase Arrest and MAPK-Mediated Mitochondrial-Derived Apoptosis in Human Acute Myeloid Leukemia Cell Lines
por: Hsiao, Pei-Ching, et al.
Publicado: (2014)

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes
por: Teng, Wei-Lin, et al.
Publicado: (2021)

Pterostilbene in Cancer Therapy
por: Obrador, Elena, et al.
Publicado: (2021)

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
por: Hsieh, Min-Hong, et al.
Publicado: (2019)

Licochalcone A-Induced Apoptosis Through the Activation of p38MAPK Pathway Mediated Mitochondrial Pathways of Apoptosis in Human Osteosarcoma Cells In Vitro and In Vivo
por: Lin, Renn-Chia, et al.
Publicado: (2019)

Synthesis and antiproliferative activity of pterostilbene and [Formula: see text] -methoxy pterostilbene Mannich base derivatives against Hela cells
por: Liu, Chongyang, et al.
Publicado: (2015)

Resveratrol and Pterostilbene, Two Analogue Phenolic Compounds, Affect Aquaglyceroporin Expression in a Different Manner in Adipose Tissue
por: Gómez-Zorita, Saioa, et al.
Publicado: (2018)

Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling
por: Wu, Min-Hua, et al.
Publicado: (2017)

Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS
por: Chen, Yi-Ting, et al.
Publicado: (2020)

Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells
por: Mori, Shiori, et al.
Publicado: (2020)

Inhibition of eIF2α dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis
por: Sequeira, Sharon J, et al.
Publicado: (2009)

Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage
por: Matsuoka, Masato, et al.
Publicado: (2015)

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
por: Crespillo-Casado, Ana, et al.
Publicado: (2017)

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs
por: Bollo, Mariana, et al.
Publicado: (2010)

A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-α (ERα) Expression in ERα-Negative Breast Cancer Cells
por: Kala, Rishabh, et al.
Publicado: (2016)

Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells
por: Xie, Weiguo, et al.
Publicado: (2021)

Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis
por: Wang, Ying-Jan, et al.
Publicado: (2017)

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-MYC dephosphorylation and degradation
por: Cianfanelli, Valentina, et al.
Publicado: (2014)

Apoptotic and Nonapoptotic Activities of Pterostilbene against Cancer
por: Chen, Rong-Jane, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d6jr4jc68a51no11ahqke82p2d