ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation

The activation of p53 tumor suppressor is essential for preventing abnormal cell proliferation and carcinogenesis. ZCCHC10 was previously identified as a potential p53-interacting partner in a yeast two-hybrid screen, but the interaction in cells and its subsequent influence on p53 activity and canc...

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Detalles Bibliográficos
Autores principales: Ning, Yichong, Hui, Na, Qing, Bei, Zhuo, Yiming, Sun, Wei, Du, Yan, Liu, Shunlian, Liu, Kaili, Zhou, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538723/
https://www.ncbi.nlm.nih.gov/pubmed/31138778
http://dx.doi.org/10.1038/s41419-019-1635-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538723/
https://www.ncbi.nlm.nih.gov/pubmed/31138778
http://dx.doi.org/10.1038/s41419-019-1635-9

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