Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1

The human proinsulin gene (INS) contains a thymine-to-adenine variant (rs689) located in the 3′ splice site (3′ ss) recognition motif of the first intron. The adenine at rs689 is strongly associated with type 1 diabetes. By weakening the polypyrimidine tract, the adenine allele reduces the efficienc...

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Detalles Bibliográficos
Autores principales: Lages, Ana, Proud, Christopher G., Holloway, John W., Vorechovsky, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539410/
https://www.ncbi.nlm.nih.gov/pubmed/31150930
http://dx.doi.org/10.1016/j.omtn.2019.04.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539410/
https://www.ncbi.nlm.nih.gov/pubmed/31150930
http://dx.doi.org/10.1016/j.omtn.2019.04.026

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