Functional Characterization of Colon Cancer-Associated Mutations in ADAM17: Modifications in the Pro-Domain Interfere with Trafficking and Maturation

Colorectal cancer is one of the most commonly diagnosed malignancies in the Western world and is associated with elevated expression and activity of epidermal growth factor receptors (EGF-R). The metalloproteinase ADAM17 is involved in EGF-R activation by processing EGF-R ligands from membrane-bound...

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Detalles Bibliográficos
Autores principales: Pavlenko, Egor, Cabron, Anne-Sophie, Arnold, Philipp, Dobert, Jan Philipp, Rose-John, Stefan, Zunke, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539446/
https://www.ncbi.nlm.nih.gov/pubmed/31060243
http://dx.doi.org/10.3390/ijms20092198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539446/
https://www.ncbi.nlm.nih.gov/pubmed/31060243
http://dx.doi.org/10.3390/ijms20092198

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